The construction and maintenance of road pavements entail detrimental impacts on the consumption of resources and damage to the natural environment but also make up an opportunity for the large-scale application of circular economy principles and innovative waste valorisation paths. The present study focuses on developing a comprehensive procedure to evaluate the technical and environmental sustainability of replacing high percentage of limestone aggregates with artificial aggregates from municipal solid waste incineration (MSWI) into hot or cold recycled asphalt mixtures for asphalt pavements. The technical feasibility of the designed mixtures was investigated in terms of the main physical and mechanical properties of both the raw materials and the asphalt mixtures with content of artificial aggregates or sand in the range 25–40 % by mass. The environmental feasibility of the asphalt mixtures was evaluated through the SEM-EDS technique, the analysis of the eluate of the leaching test and the ecotoxicity for living organisms. Afterwards, the life cycle assessment (LCA) was applied to detect the critical spots of the life cycle of 1 m2 of a 6 cm-thick binder layer with high percentage of artificial aggregates or sand built and maintained through 30 years analysis period according to 18 impact category indicators. The main results show that, recycling the artificial aggregates into hot asphalt mixtures has on average a negligible effect on the overall environmental performance of the life cycle, and appears to be detrimental only for the consumption of fossil resources due to the higher optimum bitumen content. Looking at the results for cold mixes, the introduction of the artificial aggregates has an effect on the predicted durability of the asphalt layers, which is maximized in the case of coarse artificial aggregates. Consequent environmental benefits regard the global warming potential, fossil resource scarcity and freshwater eutrophication indicators.