The JACS Au has just published an invited perspective by Dr. Saer Samanipour and his team on the daunting challenge of mapping all the chemicals around us. Samanipour, an Assistant Professor at the Van 't Hoff Institute for Molecular Sciences of the University of Amsterdam (UvA) takes inventory of the available science and concludes that currently a real pro-active chemical management is not feasible. To really get a grip on the vast and expanding chemical universe, Samanipour advocates the use of machine learning and AI, complementing existing strategies for detecting and identifying all molecules we are exposed to. In science lingo the aggregate of all the molecules we are exposed to is called the "exposome chemical space" and it is central to Samanipour's scientific endeavors. It is his mission to explore this vast molecular space and map it to the most "remote" corners. He is driven by curiosity, but even more so by necessity......